東京大学 伊藤研究室

東京大学大学院工学系研究科　化学システム工学専攻
東京大学大学院工学系研究科　バイオエンジニアリング専攻
東京大学大学院医学系研究科　生体物理医学専攻

English

Profile

    稲垣 奈都子

    電話：03-5841-1696

    Mail：ninagaki[at]g.ecc.u-tokyo.ac.jp

略歴

2023- 東京大学大学院工学系研究科化学システム工学専攻 助教
2022-2023 東京大学大学院医学系研究科疾患生命工学センター 助教
2015-2022 国立国際医療研究センター研究所 博士研究員
2011-2015 東京大学分子生物学研究所 博士研究員
2011 東京大学大学院医学系研究科病因病理学専攻 博士課程修了（医学博士）
※日本学術振興会・特別研究員DC1

研究内容

疾患メカニズムを紐解くとともに、化学工学的視点および生化学・分子生物学的視点から治療法の開発を目指す。

受賞

2024年度 第8回バイオインダストリー奨励賞
2021年度 第７回肝臓と糖尿病・代謝研究会 若手研究奨励賞
2016年度 BioLegend/Tomy Digital Biology Travel Award

招待講演

  • シンポジウム 「新規術後癒着防止材の開発と医療応用の可能性」　稲垣奈都子, 化学工学会第55回秋季大会, (2024).
  • シンポジウム 「肝疾患におけるリゾリン脂質アシル転移酵素LPCAT3/LPLAT12の役割の解明」 稲垣奈都子, 第66回脂質生化学会, (2024).
  • Workshop, “The role of Membrane phospholipids in liver diseases.” Natsuko F Inagaki, The　University of Tokyo and Seoul National University Joint Workshop on Data driven biomedical innovation, (2024).
  • シンポジウム 「光周期に異なる反応を示すマウス 視交叉上核概日振動体群とその局在」Natsuko Inagaki, 日本睡眠学会第32回定期学術大会・第14回日本時間生物学学術大会, (2007).
  • ワークショップ　「分子時計研究の最前線」　稲垣奈都子, 本間さと, 本間研一.　第13回日本時間生物学術大会, (2006).

学術論文（※ corresponding author）

  1. N. F. Inagaki※, H. Nakanishi, T. Ohto, H. Shindou, T. Shimizu, LPCAT3/LPLAT12 deficiency in the liver ameliorates acetaminophen‐induced acute liver injury, The FASEB Journal, 38(1), e23328. (2024).
  2. N. F. Inagaki, Y. Oki, S. Ikeda, S. Tulakarnwong, M. Shinohara, F. F. Inagaki, S. Ohta, N. Kokudo, Y. Sakai, T. Ito※, Transplantation of pancreatic beta-cell spheroids in mice via non-swellable hydrogel microwells composed of poly (HEMA- co-GelMA)., Biomater Sci., 12(17), 4354-4362 (2024). Front Cover
  3. Y. Dai, N. F. Inagaki, R. Ueki, S. Sando, K. Hasegawa, T. Ito※, Hepatocyte Growth Factor DNA Aptamer for Prevention of Postoperative Peritoneal Adhesion via Enhancement of Fibrinolysis and Inhibition of Mesothelial Mesenchymal Transition, ACS Appl Bio Mater., 7(7), 4679-4689 (2024). Supplementary Cover
  4. K. Mitsuhashi, N. F. Inagaki, T. Ito※, Moldable tissue sealant hydrogel composed of in situ crosslinkable polyethylene glycol via thiol-Michael addition and Carbomer, ACS Biomaterials Science & Engineering, 10(5), 3343-3354 (2024). Supplymentary Cover
  5. Q. Zhang, N. F. Inagaki, A. K. Chandel, H. Yoshida, D. Xiao, M. Kamihira, T. Hamada, S. Sagisaka, Y. Kishikawa, T. Ito※, Development of Perfluoro Decalin/Fluorinated Polyimide Core-Shell Microparticles via SPG Membrane Emulsification using Methyl Perfluoropropyl Ether Cosolvent, ACS Omega, 9(19), 21127-21135 (2024).
  6. Q. Zhang, N. F. Inagaki, Y. Hirabayashi, M. Kamihira, T. Ito※, Development of rapid hypoxia-detectable artificial oxygen carriers with a core–shell structure and erythrocyte mimetic shape, Materials Advances, DOI: 10.1039/D3MA01135F (2024). Front Cover
  7. F. Sato, H. Alejandra, H. Takemae, N. F. Inagaki, T. Ito, M. Tera※, Enhancing Cell Aggregation and Migration via Double-Click Cross-linking with Azide-Modified Hyaluronic Acid., Bioconjugate Chemistry, doi/10.1021/acs.bioconjchem.4c00221. (2024).
  8. K. Chandel, A. S. Madhavikutty, S. Okada, Z. Qiming, N. F. Inagaki, S. Ohta, T. Ito※, Injectable, shear-thinning, photocrosslinkable, and tissue-adhesive hydrogels composed of diazirine-modified hyaluronan and dendritic polyethyleneimine, Biomater Sci., 12(6), 1454-1464 (2024). Front Cover
  9. C-C. Tsai, A. K. Chandel, K, Mitsuhashi, T. Fujiyabu, N. F. Inagaki, T. Ito※, Injectable, Shear-Thinning, Self-Healing, and Self-Cross-Linkable Benzaldehyde-Conjugated Chitosan Hydrogels as a Tissue Adhesive, Biomacromolecules, 25(2), 1084-1095 (2024).
  10. M. Kamedani, M. Okawa, A. S. Madhavikutty, C-C Tsai, A. K. Chandel, T. Fujiyabu, N. F. Inagaki, T. Ito※, Injectable Extracellular Matrix-Inspired Hemostatic Hydrogel Composed of Hyaluronan and Gelatin with Shear-Thinning and Self-Healing., Biomacromolecules, 25(3), 1790-1799 (2024).
  11. K. Matsumiya, N. F. Inagaki, T. Ito※, Fabrication of Drug-Loaded Torus-Shaped Alginate Microparticles and Kinetic Analysis of Their Drug Release, Langmuir, 40: 1247–1256 (2024). Supplymentary Cover
  12. Q. Zhang, N. F. Inagaki, H. Yoshida, M. Kamihira, Y. Sakai, T. Ito※,　Development of erythrocyte-mimetic PFOB/PDMS thermoplastic elastomer core-shell microparticles via SPG membrane emulsification, Journal of Membrane Science, 689, 122119. (2024).
  13. P. Qi, Y. Tsuji, A. S. Madhavikutty, S. Ohta, A. Fujisawa, N. F. Inagaki, M. Fujishiro,T. Ito※,　Prevention of esophageal stenosis via in situ cross-linkable Alginate/Gelatin powder in a new submucosal exfoliation model in rat, Biomater Sci., 11(20), 6781-6789 (2023).
  14. Q. Zhang, N. F Inagaki, T. Ito※,　Recent advances in micro-sized oxygen carriers inspired by red blood cells, Science and Technology of Advanced Materials, 24(1), 2223050 (2023).
  15. A. S. Madhavikutty, A. K. Chandel, C-C Tsai, N. F. Inagaki, S. Ohta, T. Ito※, pH responsive cationic guar gum-borate self-healing hydrogels for muco-adhesion, Science and Technology of Advanced Materials, 24(1), 2175586 (2023).
  16. N. Nakamura, S. Ohta, M. Yamada, Y. Suzuki, N. F. Inagaki, T. Yamaguchi, T. Ito※, Development of a potassium ion-responsive star copolymer with controlled aggregation/dispersion transition, ACS Omega, 8(1), 1343–1352 (2022).
  17. WJ. Valentine S. A. Mostafa, S. M. Tokuoka SM, F. Hamano, N. F. Inagaki, J. Z. Nordin, N. Motohashi, Y. Kita, Y. Aoki, T. Shimizu, H. Shindou※, Lipidomic Analyses Reveal Specific Alterations of Phosphatidylcholine in Dystrophic Mdx Muscle, Front Physiol, 12, 698166 (2021).
  18. N. F. Inagaki※, F. F. Inagaki, N. Kokudo, A. Miyajima, Generation of mesothelial progenitor-like cells from mouse-induced pluripotent stem cells, FEBS Letters, 593(4), 386-394 (2019). Editor’s Choice。Front Cover
  19. T. Yoshikawa, N. F. Inagaki, S. Takagi, S. Kuroda, M. Yamasaki, M. Watanabe, S. Honma, KI※. Honma, Localization of photoperiod responsive circadian oscillators in the mouse suprachiasmatic nucleus, Sci Report, 7(1), 8210 (2017).
  20. N. F. Inagaki, F. F. Inagaki, N. Kokudo, A. Miyajima※, Cell-based therapy for preventing postoperative adhesion and promoting regeneration after hepatectomy, Journal of Hepato-Biliary-Pancreatic Sciences, 22(7), 524-30 (2015).
  21. N. F. Inagaki, F. F. Inagaki, N. Kokudo, A. Miyajima※, Use of mouse liver mesothelial cells to prevent postoperative adhesion and promote liver regeneration after hepatectomy, J. Hepatology, 62(5), 1141-1147 (2015).
  22. F. F. Inagaki, M.Tanaka, N. F. Inagaki, T. Yagai, Y. Sato, K. Sekiguchi, N. Oyaizu, N. Kokudo, A. Miyajima※, Nephronectin is upregulated in acute and chronic hepatitis and aggravates liver injury by recruiting CD4 positive cells, Biochem Biophys Res Commun, 430(2), 751-756 (2013).
  23. S. Honma, D. Ono, Y. Suzuki, N. Inagaki, T. Yoshikawa, W. Nakamura, K. Honma※, Suprachiasmatic nucleus: Cellular clocks and networks, Prog Brain Res., 199, 129-141 (2012).
  24. H. Takeuchi, H.Ishii, T. Kuwano, N. Inagaki, H. Akari, T. Matano※, Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication, Retrovirology, 9,3 (2012).
  25. N. Inagaki, H. Takeuchi, M. Yokoyama, H. Sato, A. Ryo, H. Yamamoto, M. Kawada, T. Matano※, A structural constraint for functional interaction between N-terminal and C-terminal domains in simian immunodeficiency virus capsid proteins, Retrovirology,7,90 (2010).
  26. S. Honma, N. Inagaki, D. Ono, T. Yoshikawa, S. Hashimoto, K. Honma※, Clock mechanisms for seasonal adaptation: Morning and evening oscillators in the　suprachiasmatic nucleus, Sleep and Biological Rhythms,6, 84-90 (2008).
  27. N. Inagaki, S. Honma, D. Ono, Y. Tanahashi, K. Honma※, Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity, Proc Natl Acad Sci USA., 104: 7664-7669 (2007).